The use of bioconjugates of porphyrin to overcome ABC drug transporter-mediated drug resistance

Barry J. Liang; Suresh V. Ambudkar; Huang-Chiao Huang

doi:10.1117/12.2609732

7 March 2022 The use of bioconjugates of porphyrin to overcome ABC drug transporter-mediated drug resistance

Barry J. Liang, Suresh V. Ambudkar, Huang-Chiao Huang

Proceedings Volume PC11940, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX; (2022) https://doi.org/10.1117/12.2609732
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Rationally designed bioconjugates of photosensitizers have been shown to enhance the photochemical effect of photodynamic therapy (PDT) via altering the sub-cellular localization of the photosensitizers or modulating the function of ATP-binding cassette (ABC) transporters. P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) are the two key members that contribute to chemoresistance and PDT resistance in cancer. Here, we introduce a porphyrin-based phospholipid conjugation strategy to circumvent and inhibit the efflux function of ABC drug transporters. Our results show the porphyrin-phospholipid conjugate enhances the photosensitizer accumulation and modulates the enzymatic activity and protein integrity of ABCB1 and ABCG2.

Conference Presentation

Citation Download Citation

Barry J. Liang, Suresh V. Ambudkar, and Huang-Chiao Huang "The use of bioconjugates of porphyrin to overcome ABC drug transporter-mediated drug resistance", Proc. SPIE PC11940, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX, (7 March 2022); https://doi.org/10.1117/12.2609732

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