Zhikai Zhuhttps://orcid.org/0000-0002-1447-3170,1 George P. Philipopoulos,1 Melody Doosty,1 Jangwoen Lee,1 David Mukai,1 Xiao Gao,2 Sari B. Mahon,1 Matthew Brenner,1 Livia A. Veress,3 Carl W. White,3 Zhongping Chen1
1Beckman Laser Institute and Medical Clinic (United States) 2Univ. of California, Riverside (United States) 3Univ. of Colorado Denver (United States)
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In this work, we demonstrate the ability to image and quantify airway changes, we were able to quantify a decrease in airway compliance. The proposed approach will enable further investigations of using OCT assessing pulmonary injury to prevent/treat ARDS using a chlorine inhalation injury model, as well as diagnosing of large airway injury and compliance change due to airway toxic chemical exposure. With enhanced portability over conventional bronchoscopy, we believe our system is capable of field hospital deployment and investigating airway conditions in warfighters. Combining OCT and pressure transducer with bronchoscopy would enhance assessment and treatment of large airway chemical injury.
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Zhikai Zhu, George P. Philipopoulos, Melody Doosty, Jangwoen Lee, David Mukai, Xiao Gao, Sari B. Mahon, Matthew Brenner, Livia A. Veress, Carl W. White, Zhongping Chen, "In-vivo airway compliance analysis of acute chlorine gas inhalation injury in rabbit model," Proc. SPIE PC11937, Endoscopic Microscopy XVII, PC119370E (7 March 2022); https://doi.org/10.1117/12.2610423