Label-free photoacoustic computed tomography of visually-evoked hemodynamic responses in the mouse brain

Kai-Wei Chang; Yunhao Zhu; Xueding Wang; Kwoon Y. Wong; Guan Xu

doi:10.1117/12.2609836

7 March 2022 Label-free photoacoustic computed tomography of visually-evoked hemodynamic responses in the mouse brain

Kai-Wei Chang, Yunhao Zhu, Xueding Wang, Kwoon Y. Wong, Guan Xu

Proceedings Volume PC11960, Photons Plus Ultrasound: Imaging and Sensing 2022; PC1196016 (2022) https://doi.org/10.1117/12.2609836
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

The current functional brain mapping techniques such as fMRI and DOI suffer from limited spatial resolution. Photoacoustic (PA) imaging combines the sensitivity of optical imaging to hemodynamic variations, and spatial resolution of ultrasound detection. In this study, we built a label-free PA computed tomography (PACT) system with a ring-shaped ultrasound array to monitor the hemodynamic changes in the primary visual cortex (V1) of mice in response to retinal photostimulation. The responses of wild-type and retinal degenerate (rd1) mice were compared. A linear-array PACT system was also used to measure the visually-evoked subcortical responses. Therefore, PACT is potential tool to study the effect of retinal degeneration of mice on the visual pathway.

Conference Presentation

Citation Download Citation

Kai-Wei Chang, Yunhao Zhu, Xueding Wang, Kwoon Y. Wong, and Guan Xu "Label-free photoacoustic computed tomography of visually-evoked hemodynamic responses in the mouse brain", Proc. SPIE PC11960, Photons Plus Ultrasound: Imaging and Sensing 2022, PC1196016 (7 March 2022); https://doi.org/10.1117/12.2609836

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