Mapping intrinsic pulsatile deformation dynamics of the murine retina and choroid with optical coherence tomography

Bernhard Baumann; Conrad W. Merkle; Marco Augustin; Martin Glösmann; Gerhard Garhöfer

doi:10.1117/12.2609651

2 March 2022 Mapping intrinsic pulsatile deformation dynamics of the murine retina and choroid with optical coherence tomography

Bernhard Baumann, Conrad W. Merkle, Marco Augustin, Martin Glösmann, Gerhard Garhöfer

Author Affiliations +

Proceedings Volume PC11962, Optical Elastography and Tissue Biomechanics VIV; PC119620F (2022) https://doi.org/10.1117/12.2609651
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Irregularities of ocular pulsatility are associated with some of the most severe eye diseases. Here we present fundus elastography (FUEL) based on optical coherence tomography (OCT) for the quantitative assessment and depth-resolved mapping of pulsatile dynamics in the murine retina and choroid. Our FUEL approach is based on an analysis of the complex OCT signal dynamics across repeated frame acquisitions. We demonstrate in vivo FUEL imaging in the retinas of wildtype mice and mouse models of retinal diseases and reveal subtle structural deformations related to ocular pulsation. Our data in mouse eyes hold promise for a powerful retinal elastography technique that may enable a new paradigm of OCT based measurements and image contrast.

Conference Presentation

Citation Download Citation

Bernhard Baumann, Conrad W. Merkle, Marco Augustin, Martin Glösmann, and Gerhard Garhöfer "Mapping intrinsic pulsatile deformation dynamics of the murine retina and choroid with optical coherence tomography", Proc. SPIE PC11962, Optical Elastography and Tissue Biomechanics VIV, PC119620F (2 March 2022); https://doi.org/10.1117/12.2609651

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