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7 March 2022 Depth-of-focus extended multi-contrast imaging by polarization-sensitive optical coherence tomography
Lida Zhu, Shuichi Makita, Daisuke Oida, Arata Miyazawa, Kensuke Oikawa, Pradipta Mukherjee, Antonia Lichtenegger, Martin Distel, Yoshiaki Yasuno
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Proceedings Volume PC11963, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2022; PC119630I (2022) https://doi.org/10.1117/12.2609200
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
A three-dimensional label-free multi-contrast imaging for ex vivo tissue investigation is presented. Computational refocusing is implemented in a Jones-matrix polarization-sensitive optical coherence tomography (PS-OCT) system to overcome the trade-off between imaging depth and lateral resolution. The application of multiple contrast imaging, including intensity, birefringence, and degree-of-polarization uniformity (DOPU), is demonstrated by phantom, porcine muscle, and zebrafish measurements. Extended imaging depth with enhanced lateral resolution over millimeter is achieved. In tissue imaging we find some altered birefringence and DOPU estimation, whose size and alteration are proportional to defocus amount. This biased estimation can be numerically mitigated after applying computational refocusing.
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Lida Zhu, Shuichi Makita, Daisuke Oida, Arata Miyazawa, Kensuke Oikawa, Pradipta Mukherjee, Antonia Lichtenegger, Martin Distel, and Yoshiaki Yasuno "Depth-of-focus extended multi-contrast imaging by polarization-sensitive optical coherence tomography", Proc. SPIE PC11963, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2022, PC119630I (7 March 2022); https://doi.org/10.1117/12.2609200
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KEYWORDS
Optical coherence tomography
Tissues
Image resolution
Optical imaging
Birefringence
3D image processing
Collagen
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