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When laser speckle contrast imaging (LSCI) is applied to in-vivo imaging in a mouse brain, the light scattering from tissue background is found to vary on millisecond time scales. Instead of treating background scattering as static, we present a method of LSCI analysis that fully incorporates the dynamics of background scattering. Fast and slow scattering components are distinguished by a method of clustering, enabling a determination of their relative weights. We further show that the speckle correlation time can be directly reconstructed rather than fitted to a model, thus achieving much faster processing speed.
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Shuqi Zheng, Lisa Kretsge, Alberto Cruz-Martín, Jerome Mertz, "Correction for background scattering dynamics in quantitative laser speckle contrast imaging," Proc. SPIE PC11974, Biomedical Applications of Light Scattering XII, PC119740A (3 March 2022); https://doi.org/10.1117/12.2608356