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4 March 2022 Optical modulation biosensing platform for high sensitivity and high throughput detection of antigens and specific RNA sequences
Shmuel Burg, Shira Roth, Meir Cohen, Shira Avivi-Mintz, Michael Margulis, Amos Danielli
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Proceedings Volume PC11979, Frontiers in Biological Detection: From Nanosensors to Systems XIV; PC1197902 (2022) https://doi.org/10.1117/12.2612537
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
Detection of biomarkers at low concentrations is essential for early diagnosis of numerous diseases. In many sensitive assays, the target molecules are tagged using fluorescently labeled probes and captured using magnetic beads. Current devices rely on quantifying the target molecules by detecting the fluorescent signal from individual beads. Here, we demonstrate a high-throughput optical modulation biosensing (ht-OMB) system Using the ht-OMB system to detect human Interleukin-8, we demonstrated a limit of detection of 0.14 ng/L and a 4-log dynamic range, values which are on par with the most sensitive devices, but are achieved without their bulk and laborious protocols.
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Shmuel Burg, Shira Roth, Meir Cohen, Shira Avivi-Mintz, Michael Margulis, and Amos Danielli "Optical modulation biosensing platform for high sensitivity and high throughput detection of antigens and specific RNA sequences", Proc. SPIE PC11979, Frontiers in Biological Detection: From Nanosensors to Systems XIV, PC1197902 (4 March 2022); https://doi.org/10.1117/12.2612537
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KEYWORDS
Biosensing
Modulation
Signal detection
Molecules
Target detection
Magnetism
Phase shift keying
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