Large-volume deep-brain function imaging via clear optically matched panoramic access channel technique (COMPACT)

Meng Cui; Chenmao Wang; Zongyue Cheng

doi:10.1117/12.2650442

17 March 2023 Large-volume deep-brain function imaging via clear optically matched panoramic access channel technique (COMPACT)

Meng Cui, Chenmao Wang, Zongyue Cheng

Author Affiliations +

Proceedings Volume PC12365, Neural Imaging and Sensing 2023; PC123650D (2023) https://doi.org/10.1117/12.2650442
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Optical calcium imaging has been widely used in neuroscience. However, a major limitation of optical measurement is the limited imaging depth in live mammalian brain tissue. Although miniature optical imaging probes have been employed to access the deep brain regions, their imaging field-of-view is very limited, resulting in low measurement throughput and success rate. Recently, we have developed the Clear Optically Matched Panoramic Access Channel Technique (COMPACT), which can improve the tissue access volume by two to three orders of magnitude. Here, we present our latest results of 0.5 mm diameter COMPACT systems.

Conference Presentation

Citation Download Citation

Meng Cui, Chenmao Wang, and Zongyue Cheng "Large-volume deep-brain function imaging via clear optically matched panoramic access channel technique (COMPACT)", Proc. SPIE PC12365, Neural Imaging and Sensing 2023, PC123650D (17 March 2023); https://doi.org/10.1117/12.2650442

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