Advances in non-genetic photoacoustic neuromodulation: Mechanism and close-looped capability

Chen Yang

doi:10.1117/12.2650079

17 March 2023 Advances in non-genetic photoacoustic neuromodulation: Mechanism and close-looped capability

Chen Yang

Proceedings Volume PC12366, Optogenetics and Optical Manipulation 2023; PC1236609 (2023) https://doi.org/10.1117/12.2650079
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

High precision neuromodulation is a powerful tool for fundamental studies in neuroscience and potential treatments for neurological disorders. Recently photoacoustic stimulation has been showed as a non-genetic high precision method in vitro and in vivo. Here we report new insights on cellular mechanism of photoacoustic stimulation. Specifically, we showed the direct involvement of mechanosensitive ion channels during fiber based photoacoustic stimulation using sonogenetics. In addition, we also report the development of a miniaturized fiber stimulator integrating with electrodes for simultaneous stimulation and recording. Such devices are used for closed-loop stimulation in deep brain stimulation as a potential clinical application.

Conference Presentation

Citation Download Citation

Chen Yang "Advances in non-genetic photoacoustic neuromodulation: Mechanism and close-looped capability", Proc. SPIE PC12366, Optogenetics and Optical Manipulation 2023, PC1236609 (17 March 2023); https://doi.org/10.1117/12.2650079

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