Functionally multiplexed optical coherence tomography for comprehensive and volumetric analysis of tissue microstructure

Taylor M. Cannon; Rachel H. Chae; Brett E. Bouma; Néstor Uribe-Patarroyo

doi:10.1117/12.2652969

9 March 2023 Functionally multiplexed optical coherence tomography for comprehensive and volumetric analysis of tissue microstructure

Taylor M. Cannon, Rachel H. Chae, Brett E. Bouma, Néstor Uribe-Patarroyo

Author Affiliations +

Proceedings Volume PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII; PC123670T (2023) https://doi.org/10.1117/12.2652969
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Functional extensions of Optical Coherence Tomography (OCT) stand to enhance the value of structural imaging for clinical applications. Polarization sensitive (PS-) OCT and attenuation coefficient imaging provide complementary information useful for interrogating complex tissue microenvironments such as atherosclerotic plaques. However, additional hardware for generating two input polarization states, and enabling angular-diverse measurements, is necessary to fully exploit these two respective techniques. We present a platform for simultaneous, depth-multiplexed acquisition of PS- and angular diverse data, expanding prior methods for fiber-based PS-OCT and aperture-based numerical aperture (NA) multiplexing, and demonstrate its utility in discriminating plaque components in human coronary arteries.

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Taylor M. Cannon, Rachel H. Chae, Brett E. Bouma, and Néstor Uribe-Patarroyo "Functionally multiplexed optical coherence tomography for comprehensive and volumetric analysis of tissue microstructure", Proc. SPIE PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII, PC123670T (9 March 2023); https://doi.org/10.1117/12.2652969

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KEYWORDS

Optical coherence tomography

Multiplexing

Signal attenuation

Tissue optics

Arteries

Data acquisition

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