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9 March 2023 In-vivo polarization sensitive optical coherence tomography for fibrosis quantification in interstitial lung disease
Margherita Vaselli, Kirsten Kalverda, Jouke Annema, Peter Bonta, Johannes F. de Boer
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Proceedings Volume PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII; PC1236712 (2023) https://doi.org/10.1117/12.2652829
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Endobronchial polarization sensitive optical coherence tomography (PS-OCT) provides high-resolution images and can detect tissue birefringence. Using collagen birefringent properties, we postulated that PS-OCT can detect and quantify pulmonary fibrosis in interstitial lung disease (ILD) patients. In this study, we demonstrated PS-OCT in 19 patients (16 ILD and 3 non-fibrotic controls). In-vivo PS-OCT was performed by advancing a distal scanning endoscope through the working channel of a bronchoscope to the lung periphery of the patients. Results show that PS-OCT is feasible, safe, and can quantify pulmonary fibrosis, thereby has potential as minimally invasive diagnostic tool to detect fibrotic progression in ILD.
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Margherita Vaselli, Kirsten Kalverda, Jouke Annema, Peter Bonta, and Johannes F. de Boer "In-vivo polarization sensitive optical coherence tomography for fibrosis quantification in interstitial lung disease", Proc. SPIE PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII, PC1236712 (9 March 2023); https://doi.org/10.1117/12.2652829
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KEYWORDS
Lung
In vivo imaging
Optical coherence tomography
Polarization
Biopsy
Image segmentation
Pulmonary fibrosis
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