Intracellular hexagonal boron nitride color centers for cellular barcoding

Aljaž Kavcic; Rok Podlipec; Daniele Vella; Matjaž Humar

doi:10.1117/12.2692499

13 March 2024 Intracellular hexagonal boron nitride color centers for cellular barcoding

Aljaž Kavcic, Rok Podlipec, Daniele Vella, Matjaž Humar

Proceedings Volume PC12863, Quantum Effects and Measurement Techniques in Biology and Biophotonics; PC128630Q (2024) https://doi.org/10.1117/12.2692499
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

We demonstrated single-photon emission from hBN color centers embedded inside live cells and their application to cellular barcoding. Each color center can exist in one out of 470 possible distinguishable states. A combination of a few color centers per cell can be used to uniquely tag virtually an unlimited number of cells. This barcoding technique is superior to others in almost all respects, including ease of production by a single-step procedure, biocompatibility and biodegradability, emission stability, no photobleaching, small size and a huge number of unique barcodes.

Conference Presentation

Citation Download Citation

Aljaž Kavcic, Rok Podlipec, Daniele Vella, and Matjaž Humar "Intracellular hexagonal boron nitride color centers for cellular barcoding", Proc. SPIE PC12863, Quantum Effects and Measurement Techniques in Biology and Biophotonics, PC128630Q (13 March 2024); https://doi.org/10.1117/12.2692499

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