Novel Phenothiazinium Photosensitizers For Photodynamic Therapy

Louis Cincotta; James W. Foley; Anthony H. Cincotta

doi:10.1117/12.960198

17 March 1989 Novel Phenothiazinium Photosensitizers For Photodynamic Therapy

Louis Cincotta, James W. Foley, Anthony H. Cincotta

Proceedings Volume 0997, Advances in Photochemotherapy; (1989) https://doi.org/10.1117/12.960198
Event: O-E/Fiber LASE '88, 1988, Boston, MA, United States

Abstract

The replament of the oxygen atom in benzophenoxazines with sulfur leads to the corresponding phenothiazinium ehromophorus The effect that this change, as well as other structural alterations, has on photosensitized singlet oxygen formation partitioning coefficient, and in-vitro phototoxicity is presented. A brief discussion concerning how structural modifications can bring about changes in these parameters is also presented. Preliminary results suggest that some phenothiazines could be promising photosensitizers for photodynamic therapy.

Citation Download Citation

Louis Cincotta, James W. Foley, and Anthony H. Cincotta "Novel Phenothiazinium Photosensitizers For Photodynamic Therapy", Proc. SPIE 0997, Advances in Photochemotherapy, (17 March 1989); https://doi.org/10.1117/12.960198

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