Gold nano sphere based fiber optic LSPR probe for biosensing measurement

Lixia Li; Zigeng Liu; Shimeng Chen; Jianye Guang; Wei Peng

doi:10.1117/12.2245960

4 November 2016 Gold nano sphere based fiber optic LSPR probe for biosensing measurement

Lixia Li, Zigeng Liu, Shimeng Chen, Jianye Guang, Wei Peng

Proceedings Volume 10027, Nanophotonics and Micro/Nano Optics III; 100270M (2016) https://doi.org/10.1117/12.2245960
Event: SPIE/COS Photonics Asia, 2016, Beijing, China

Abstract

We present a localized surface plasmon resonance fiber optic biosensor based on an intensity interrogation mechanism. A layer of gold nano sphere is deposited on a fiber optic sensor probe which works as the sensing element and is immobilized on the sidewall of an unclad optical fiber via two different immobilization methods (amino silane method and layer by layer self-assembly method). Different self-assembly layers were also respectively investigated by using layer by layer self-assembly method to explore the optimum layer number. Experimental results reveal that PDDA/PSS/PAH layer self-assembly method provides the best LSPR response. We obtain a refractive index sensitivity as 6.57RIU^-1 in a RI range of 1.3266~1.3730. We also conduct real-time and label free monitoring of Ribonuclease B/Con A biomolecular interaction by using this sensor prototype and demonstrate it can perform qualitative and quantitative detection in real-time biomolecular sensing.

Citation Download Citation

Lixia Li, Zigeng Liu, Shimeng Chen, Jianye Guang, and Wei Peng "Gold nano sphere based fiber optic LSPR probe for biosensing measurement", Proc. SPIE 10027, Nanophotonics and Micro/Nano Optics III, 100270M (4 November 2016); https://doi.org/10.1117/12.2245960

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KEYWORDS

Gold

Refractive index

Optical spheres

Sensors

Dielectrics

Optical fibers

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