Angular compounded OCTA for flow contrast enhancement (Conference Presentation)

Peng Li; Pei Li; Yuxuan Cheng; Liping Zhou; Zhihua Ding

doi:10.1117/12.2254751

19 April 2017 Angular compounded OCTA for flow contrast enhancement (Conference Presentation)

Peng Li, Pei Li, Yuxuan Cheng, Liping Zhou, Zhihua Ding

Proceedings Volume 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI; 1005314 (2017) https://doi.org/10.1117/12.2254751
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Optical coherence tomography angiography (OCTA) is a promising imaging modality that enables a label-free, high-resolution and high-contrast image of biological tissue microvasculature. Typically, the blood flow contrast is implemented by mathematically analyzing the temporal dynamics of light scattering, and setting a threshold to distinguish the dynamic blood flow from the static tissue bed. However, high flow contrast is degraded by the residual overlap that results in misclassification errors between dynamic and static signals. Our study has demonstrated that flow contrast can be enhanced using a single-shot angular compounded OCTA (AC-OCTA). Because a continuous modulation is induced by the offset that the probing beam is away from the beam center in the typical OCT sample arm, different incidence angles in the probing beam are encoded in B-scan modulation frequencies. The complex-valued spectral interferogram is reconstructed by removing the conjugate terms in the depth space and its Fourier transform along the transversal fast-scan direction generates a wide conjugate-free B-scan modulation spectrum in the full space of the spatial domain. By splitting the modulation spectrum, angle-resolved independent sub-angiograms are generated and then compounded to enhance the flow contrast. Both flow phantom and in vivo animal cerebral vascular imaging demonstrated that the proposed angular compounded OCTA can offer a ~50% decrease of misclassification errors and an improved flow contrast and vessel connectivity. This AC-OCTA is beneficial to facilitating the interpretation of OCT angiograms in clinical applications.

Conference Presentation

Citation Download Citation

Peng Li, Pei Li, Yuxuan Cheng, Liping Zhou, and Zhihua Ding "Angular compounded OCTA for flow contrast enhancement (Conference Presentation)", Proc. SPIE 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, 1005314 (19 April 2017); https://doi.org/10.1117/12.2254751

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KEYWORDS

Modulation

Optical coherence tomography

Angiography

Blood circulation

Tissue optics

Biological research

Fourier transforms

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