Resonance Raman of BCC and normal skin

Cheng-hui Liu; Vidyasagar Sriramoju; Susie Boydston-White; Binlin Wu; Chunyuan Zhang; Zhe Pei; Laura Sordillo; Hugh Beckman M.D.; Robert R. Alfano

doi:10.1117/12.2254628

17 February 2017 Resonance Raman of BCC and normal skin

Cheng-hui Liu, Vidyasagar Sriramoju, Susie Boydston-White, Binlin Wu, Chunyuan Zhang, Zhe Pei, Laura Sordillo, Hugh Beckman M.D., Robert R. Alfano

Author Affiliations +

Proceedings Volume 10060, Optical Biopsy XV: Toward Real-Time Spectroscopic Imaging and Diagnosis; 100601B (2017) https://doi.org/10.1117/12.2254628
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

The Resonance Raman (RR) spectra of basal cell carcinoma (BCC) and normal human skin tissues were analyzed using 532nm laser excitation. RR spectral differences in vibrational fingerprints revealed skin normal and cancerous states tissues. The standard diagnosis criterion for BCC tissues are created by native RR biomarkers and its changes at peak intensity. The diagnostic algorithms for the classification of BCC and normal were generated based on SVM classifier and PCA statistical method. These statistical methods were used to analyze the RR spectral data collected from skin tissues, yielding a diagnostic sensitivity of 98.7% and specificity of 79% compared with pathological reports.

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Cheng-hui Liu, Vidyasagar Sriramoju, Susie Boydston-White, Binlin Wu, Chunyuan Zhang, Zhe Pei, Laura Sordillo, Hugh Beckman M.D., and Robert R. Alfano "Resonance Raman of BCC and normal skin", Proc. SPIE 10060, Optical Biopsy XV: Toward Real-Time Spectroscopic Imaging and Diagnosis, 100601B (17 February 2017); https://doi.org/10.1117/12.2254628

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