Cancer cell death processes in combining photothermal and photodynamic effects through surface plasmon resonance of gold nanoring (Conference Presentation)

Yulu He; Jian-He Yu; Jen-Hung Hsiao; Yi-Chou Tu; Meng Chun Low; Wei-Hsiang Hua; Cheng-Che Hsieh; Yean-Woei Kiang; Chih-Chung Yang; Zhenxi Zhang

doi:10.1117/12.2249543

24 April 2017 Cancer cell death processes in combining photothermal and photodynamic effects through surface plasmon resonance of gold nanoring (Conference Presentation)

Yulu He, Jian-He Yu, Jen-Hung Hsiao, Yi-Chou Tu, Meng Chun Low, Wei-Hsiang Hua, Cheng-Che Hsieh, Yean-Woei Kiang, Chih-Chung Yang, Zhenxi Zhang

Author Affiliations +

Proceedings Volume 10078, Colloidal Nanoparticles for Biomedical Applications XII; 1007811 (2017) https://doi.org/10.1117/12.2249543
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

In combining the photothermal and photodynamic effects for killing cancer cells through the localized surface plasmon resonance (LSP) of photosensitizer-linked Au nanorings (NRIs), which are up-taken by the cells, the cells can be killed via different processes, including necrosis and apoptosis. In particular, the dominating effect, either photothermal or photodynamic effect, for cancer cell killing leading to either necrosis or apoptosis process is an important issue to be understood for improving the therapy efficiency. In this paper, we demonstrate the study results in differentiating the necrosis and apoptosis processes of cell death under different laser illumination conditions. With the LSP resonance wavelength of the Au NRIs around 1064 nm, the illumination of a 1064-nm cw laser can mainly produce the photothermal effect. The illumination of a 1064-nm fs laser can lead to LSP resonance-assisted two-photon absorption of the photosensitizer (AlPcS) for generating singlet oxygen and hence the photodynamic effect, besides the photothermal effect. Also, the illumination of a 660-nm cw laser can result in single-photon absorption of the photosensitizer for generating singlet oxygen and the photodynamic effect. By comparing the necrosis and apoptosis distributions in dead cells between the cases of different laser illumination conditions, we can differentiate the cancer cell killing processes between the photothermal effect, photodynamic effect, and the mixed effect.

Conference Presentation

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Yulu He, Jian-He Yu, Jen-Hung Hsiao, Yi-Chou Tu, Meng Chun Low, Wei-Hsiang Hua, Cheng-Che Hsieh, Yean-Woei Kiang, Chih-Chung Yang, and Zhenxi Zhang "Cancer cell death processes in combining photothermal and photodynamic effects through surface plasmon resonance of gold nanoring (Conference Presentation)", Proc. SPIE 10078, Colloidal Nanoparticles for Biomedical Applications XII, 1007811 (24 April 2017); https://doi.org/10.1117/12.2249543

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KEYWORDS

Photothermal effect

Cell death

Cancer

Gold

Surface plasmons

Absorption

Continuous wave operation

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