Contrast-enhanced optical coherence microangiography with acoustic-actuated microbubbles

Yu-Hsuan Liu; Jia-Wei Zhang; Chih-Kuang Yeh; Kuo-Chen Wei; Hao-Li Liu; Meng-Tsan Tsai

doi:10.1117/12.2269408

18 April 2017 Contrast-enhanced optical coherence microangiography with acoustic-actuated microbubbles

Yu-Hsuan Liu, Jia-Wei Zhang, Chih-Kuang Yeh, Kuo-Chen Wei, Hao-Li Liu, Meng-Tsan Tsai

Proceedings Volume 10251, Biomedical Imaging and Sensing Conference; 102511F (2017) https://doi.org/10.1117/12.2269408
Event: SPIE Technologies and Applications of Structured Light, 2017, Yokohama, Japan

Abstract

In this study, we propose to use gas-filled microbubbles (MBs) simultaneously actuated by the acoustic wave to enhance the imaging contrast of optical coherence tomography (OCT)-based angiography. In the phantom experiments, MBs can result in stronger backscattered intensity, enabling to enhance the contrast of OCT intensity image. Moreover, simultaneous application of low-intensity acoustic wave enables to temporally induce local vibration of particles and MBs in the vessels, resulting in time-variant OCT intensity which can be used for enhancing the contrast of OCT intensitybased angiography. Additionally, different acoustic modes and different acoustic powers to actuate MBs are performed and compared to investigate the feasibility of contrast enhancement. Finally, animal experiments are performed. The findings suggest that acoustic-actuated MBs can effectively enhance the imaging contrast of OCT-based angiography and the imaging depth of OCT angiography is also extended.

Citation Download Citation

Yu-Hsuan Liu, Jia-Wei Zhang, Chih-Kuang Yeh, Kuo-Chen Wei, Hao-Li Liu, and Meng-Tsan Tsai "Contrast-enhanced optical coherence microangiography with acoustic-actuated microbubbles", Proc. SPIE 10251, Biomedical Imaging and Sensing Conference, 102511F (18 April 2017); https://doi.org/10.1117/12.2269408

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KEYWORDS

Optical coherence tomography

Acoustics

Angiography

Particles

Capillaries

Coherence (optics)

Tissues

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