Polarization-interference mapping of biological fluids polycrystalline films in differentiation of weak changes of optical anisotropy

V. O. Ushenko; O. Vanchuliak; M. Yu. Sakhnovskiy; O. V. Dubolazov; P. Grygoryshyn; I. V. Soltys; O. V. Olar; A. Antoniv

doi:10.1117/12.2273794

19 September 2017 Polarization-interference mapping of biological fluids polycrystalline films in differentiation of weak changes of optical anisotropy

V. O. Ushenko, O. Vanchuliak, M. Yu. Sakhnovskiy, O. V. Dubolazov, P. Grygoryshyn, I. V. Soltys, O. V. Olar, A. Antoniv

Author Affiliations +

Proceedings Volume 10396, Applications of Digital Image Processing XL; 103962O (2017) https://doi.org/10.1117/12.2273794
Event: SPIE Optical Engineering + Applications, 2017, San Diego, California, United States

Abstract

The theoretical background of the azimuthally stable method of polarization-interference mapping of the histological sections of the biopsy of the prostate tissue on the basis of the spatial frequency selection of the mechanisms of linear and circular birefringence is presented. The diagnostic application of a new correlation parameter – complex degree of mutual anisotropy – is analytically substantiated. The method of measuring coordinate distributions of complex degree of mutual anisotropy with further spatial filtration of their high- and low-frequency components is developed. The interconnections of such distributions with parameters of linear and circular birefringence of prostate tissue histological sections are found. The objective criteria of differentiation of benign and malignant conditions of prostate tissue are determined.

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V. O. Ushenko, O. Vanchuliak, M. Yu. Sakhnovskiy, O. V. Dubolazov, P. Grygoryshyn, I. V. Soltys, O. V. Olar, and A. Antoniv "Polarization-interference mapping of biological fluids polycrystalline films in differentiation of weak changes of optical anisotropy", Proc. SPIE 10396, Applications of Digital Image Processing XL, 103962O (19 September 2017); https://doi.org/10.1117/12.2273794

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