Stokes polarimetry probe for skin lesion evaluation: preliminary results

Daniel C. Louie; Lioudmilla Tchvialeva; Sunil Kalia; Harvey Lui; Tim K. Lee

doi:10.1117/12.2288761

14 February 2018 Stokes polarimetry probe for skin lesion evaluation: preliminary results

Daniel C. Louie, Lioudmilla Tchvialeva, Sunil Kalia, Harvey Lui, Tim K. Lee

Proceedings Volume 10467, Photonics in Dermatology and Plastic Surgery 2018; 104670X (2018) https://doi.org/10.1117/12.2288761
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

This paper reports on the design of a prototype in-vivo Stokes polarimetry probe for skin lesion evaluation, and preliminary results from skin phantom and clinical trials of this device. The probe releases a single millisecond-long pulse from a laser diode with either linear or circular polarization. It then captures the resulting backscattered far-field polarization speckle and calculates the Stokes parameters. This probe was designed with three novel innovations in mind. First, the Stokes vector is captured quickly, using low-cost components without the use of moving parts. Second, a compact collimated laser diode was used as the light source. Third, the device and detector geometry were designed to produce and capture a uniform speckle field. In the first clinical trial of this device, measurements were taken from a variety of skin lesions, both cancerous and benign. The Stokes vector was measured and used to calculate the degree of polarization (DOP), the azimuth angle, and the ellipticity angle of the polarization ellipse for two input light polarizations. Among other findings, the DOP for circular polarized input light was consistently lower than the DOP for linear polarized input light. These findings indicate the potential for a fast and low-cost in-vivo skin cancer screening tool, and encourages the continuing development of this probe’s techniques.

Citation Download Citation

Daniel C. Louie, Lioudmilla Tchvialeva, Sunil Kalia, Harvey Lui, and Tim K. Lee "Stokes polarimetry probe for skin lesion evaluation: preliminary results", Proc. SPIE 10467, Photonics in Dermatology and Plastic Surgery 2018, 104670X (14 February 2018); https://doi.org/10.1117/12.2288761

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