CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume 10471 > Article
Presentation
14 March 2018 Cellular-resolution, extended depth of focus optical coherence tomography catheter toward in vivo cardiovascular imaging (Conference Presentation)
Biwei Yin, Zhonglie Piao, Chulho Daryl Hyun, Kensuke Nishimiya, Joseph A. Gardecki, Guillermo J. Tearney M.D.
Author Affiliations +
Proceedings Volume 10471, Diagnostic and Therapeutic Applications of Light in Cardiology 2018; 104710B (2018) https://doi.org/10.1117/12.2288747
Event: SPIE BiOS, 2018, San Francisco, California, United States
Abstract
Optical coherence tomography (OCT) has been a useful clinical tool for diagnosing coronary artery disease through a flexible catheter, but its full promise relies on resolving cellular and sub-cellular structures in vivo. Previously, visualizing cellular structures through an imaging catheter is not possible due to limited depth of focus (DOF) of a tightly focused Gaussian beam: typically, a Gaussian beam with 2-3 μm resolution has a DOF within 100 μm, which is not sufficient for in vivo catheter imaging. Therefore, we developed a self-imaging wavefront division optical system that generates a coaxially-focused multimode (CAFM) beam with a DOF that is approximately one order of magnitude longer than that of a Gaussian beam. In this study, we present a high-resolution, extended DOF catheter based on self-imaging wavefront division optics. The catheter generates a CAFM beam with a lateral resolution of 3 μm and a DOF close to 2 mm. To correct the aberration introduced by catheter sheath, we incorporated a cylindrical prism to compensate the sheath astigmatism. When the catheter is incorporated into a micro-resolution OCT (μOCT) system with rotational scanning mechanics, cellular-resolution cross-sectional images of the coronary artery wall can be obtained. The device serves as an important step toward characterizing cellular and sub-cellular structures in vivo for coronary artery disease diagnosis.
Conference Presentation
© (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Biwei Yin, Zhonglie Piao, Chulho Daryl Hyun, Kensuke Nishimiya, Joseph A. Gardecki, and Guillermo J. Tearney M.D. "Cellular-resolution, extended depth of focus optical coherence tomography catheter toward in vivo cardiovascular imaging (Conference Presentation)", Proc. SPIE 10471, Diagnostic and Therapeutic Applications of Light in Cardiology 2018, 104710B (14 March 2018); https://doi.org/10.1117/12.2288747
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Optical coherence tomography
In vivo imaging
Arteries
Gaussian beams
Cardiovascular magnetic resonance imaging
Wavefronts
Endoscopy
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top