Investigation in clinical potential of polarization sensitive optical coherence tomography in laryngeal tumor model study

Xin Zhou; Chulho Oak; Yeh-Chan Ahn; Sung Won Kim; Shuo Tang

doi:10.1117/12.2292021

14 February 2018 Investigation in clinical potential of polarization sensitive optical coherence tomography in laryngeal tumor model study

Xin Zhou, Chulho Oak, Yeh-Chan Ahn, Sung Won Kim, Shuo Tang

Author Affiliations +

Proceedings Volume 10483, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII; 1048339 (2018) https://doi.org/10.1117/12.2292021
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Polarization-sensitive optical coherence tomography (PS-OCT) is capable of measuring tissue birefringence. It has been widely applied to access the birefringence in tissues such as skin and cartilage. The vocal cord tissue consists of three anatomical layers from the surface to deep inside, the epithelium that contains almost no collagen, the lamina propria that is composed with abundant collagen, and the vocalis muscle layer. Due to the variation in the organization of collagen fibers, the different tissue layers show different tissue birefringence, which can be evaluated by PS-OCT phase retardation measurement. Furthermore, collagen fibers in healthy connective tissues are usually well organized, which provides relatively high birefringence. When the collagen organization is destroyed by diseases such as tumor, the birefringence of the tissue will decrease. In this study, a rabbit laryngeal tumor model with different stages of tumor progression is investigated ex-vivo by PS-OCT. The PS-OCT images show a gradual decrease in birefringence from normal tissue to severe tumor tissue. A phase retardation slope-based analysis is conducted to distinguish the epithelium, lamina propria, and muscle layers, respectively. The phase retardation slope quantifies the birefringence in different layers. The quantitative study provides a more detailed comparison among different stages of the rabbit laryngeal tumor model. The PS-OCT result is validated by the corresponding histology images of the same samples.

Citation Download Citation

Xin Zhou, Chulho Oak, Yeh-Chan Ahn, Sung Won Kim, and Shuo Tang "Investigation in clinical potential of polarization sensitive optical coherence tomography in laryngeal tumor model study", Proc. SPIE 10483, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII, 1048339 (14 February 2018); https://doi.org/10.1117/12.2292021

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