Blood glucose measurement with multiple quantum cascade lasers using hollow-optical fiber-based ATR spectroscopy

K. Yoshioka; S. Kino; Y. Matsuura

doi:10.1117/12.2288131

13 February 2018 Blood glucose measurement with multiple quantum cascade lasers using hollow-optical fiber-based ATR spectroscopy

K. Yoshioka, S. Kino, Y. Matsuura

Author Affiliations +

Proceedings Volume 10488, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII; 104880D (2018) https://doi.org/10.1117/12.2288131
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

For non-invasive blood glucose measurement, a measurement system based on mid-infrared ATR spectroscopy equipped with a combination of a QCL as a light source and a hollow-optical fiber as a beam delivery medium is developed. Firstly the measurement sensitivity of the system is evaluated by using glucose solutions and the result shows a significant correlation between optical absorbance and solution concentration. It is also confirmed that the system has a sensitivity that is enough for blood glucose measurement. Then optical absorption of human lips in the mid-infrared wavelength region is measured using a QCL with a wavenumber of 1080 cm^-1 where human tissue exhibits strong absorption of glucose and its metabolites. As a result, the measured absorption follows the change of blood glucose well with a time delay of around 10 minutes and correlation factor between the absorbance and the blood glucose level is 0.42.

Conference Presentation

Citation Download Citation

K. Yoshioka, S. Kino, and Y. Matsuura "Blood glucose measurement with multiple quantum cascade lasers using hollow-optical fiber-based ATR spectroscopy", Proc. SPIE 10488, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII, 104880D (13 February 2018); https://doi.org/10.1117/12.2288131

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