Noninvasive optical monitoring multiple physiological parameters response to cytokine storm

Zebin Li; Ting Li

doi:10.1117/12.2288665

19 February 2018 Noninvasive optical monitoring multiple physiological parameters response to cytokine storm

Zebin Li, Ting Li

Proceedings Volume 10489, Optical Biopsy XVI: Toward Real-Time Spectroscopic Imaging and Diagnosis; 104890N (2018) https://doi.org/10.1117/12.2288665
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Cancer and other disease originated by immune or genetic problems have become a main cause of death. Gene/cell therapy is a highlighted potential method for the treatment of these diseases. However, during the treatment, it always causes cytokine storm, which probably trigger acute respiratory distress syndrome and multiple organ failure. Here we developed a point-of-care device for noninvasive monitoring cytokine storm induced multiple physiological parameters simultaneously. Oxy-hemoglobin, deoxy-hemoglobin, water concentration and deep-tissue/tumor temperature variations were simultaneously measured by extended near infrared spectroscopy. Detection algorithms of symptoms such as shock, edema, deep-tissue fever and tissue fibrosis were developed and included. Based on these measurements, modeling of patient tolerance and cytokine storm intensity were carried out. This custom device was tested on patients experiencing cytokine storm in intensive care unit. The preliminary data indicated the potential of our device in popular and milestone gene/cell therapy, especially, chimeric antigen receptor T-cell immunotherapy (CAR-T).

Conference Presentation

Citation Download Citation

Zebin Li and Ting Li "Noninvasive optical monitoring multiple physiological parameters response to cytokine storm", Proc. SPIE 10489, Optical Biopsy XVI: Toward Real-Time Spectroscopic Imaging and Diagnosis, 104890N (19 February 2018); https://doi.org/10.1117/12.2288665

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