OCT angiography reveals age-related differences in cerebral blood flow of anesthetized mice (Conference Presentation)

Woo June Choi; Yuandong Li; Wei Wei; Ruikang K. Wang

doi:10.1117/12.2291096

14 March 2018 OCT angiography reveals age-related differences in cerebral blood flow of anesthetized mice (Conference Presentation)

Woo June Choi, Yuandong Li, Wei Wei, Ruikang K. Wang

Author Affiliations +

Proceedings Volume 10493, Dynamics and Fluctuations in Biomedical Photonics XV; 104930J (2018) https://doi.org/10.1117/12.2291096
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Normal aging is associated with various metabolic and vascular changes. In the brain, the aging leads to an impairment of vessel structure and function. Characterizing the cerebrovascular pathologies with age is of importance to elucidate the underlying mechanism of cognitive decline correlated with blood perfusion. Here, we examine the effect of aging on cerebral microcirculation up to a capillary flow scale. This study uses optical coherence tomography angiography (OCTA) to measure vessel tortuosity, red blood cell (RBC) speed in individual capillaries and capillary density in the sensory-motor cortex of 8 young (3-month-old) and 8 aged (16-month-old) mice under isoflurane anesthesia. The result shows that the surface arterial vessels are more tortuous and the capillary RBC speed is much higher in aged animals old compared with young ones. However, the capillary vessel density is significantly lowered in the aged group than the young group.

Conference Presentation

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Woo June Choi, Yuandong Li, Wei Wei, and Ruikang K. Wang "OCT angiography reveals age-related differences in cerebral blood flow of anesthetized mice (Conference Presentation)", Proc. SPIE 10493, Dynamics and Fluctuations in Biomedical Photonics XV, 104930J (14 March 2018); https://doi.org/10.1117/12.2291096

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KEYWORDS

Capillaries

Angiography

Blood

Cerebral blood flow

Optical coherence tomography

Brain

Functional imaging

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