Laser-assisted nanoceramics reinforced polymer scaffolds for tissue engineering: additional heating and stem cells behavior

Igor Shishkovsky; Vladimir Scherbakov; Vladislav Volchkov; Larisa Volova

doi:10.1117/12.2290583

14 February 2018 Laser-assisted nanoceramics reinforced polymer scaffolds for tissue engineering: additional heating and stem cells behavior

Igor Shishkovsky, Vladimir Scherbakov, Vladislav Volchkov, Larisa Volova

Author Affiliations +

Proceedings Volume 10493, Dynamics and Fluctuations in Biomedical Photonics XV; 104931T (2018) https://doi.org/10.1117/12.2290583
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

The conditions of selective laser melting (SLM) of tissue engineering scaffolds affect cell response and must be engineered to support cell adhesion, proliferation, and differentiation. In the present study, the influence of additional heating during SLM process on stem cell viability near biopolymer matrix reinforced by nanoceramics additives was carried out. We used the biocompatible and bioresorbable polymers (polyetheretherketone /PEEK/ and polycaprolactone /PCL/) as a matrix and nano-oxide ceramics - TiO₂, A_l2O₃, ZrO₂, FexOy and/or hydroxyapatite as a basis of the additives. The rate of pure PEEK and PCL bio-resorption and in mixtures with nano oxides on the matrix was studied by the method of mass loss on bacteria of hydroxylase and enzyme complex. The stem cellular morphology, proliferative MMSC activity, and adhesion of the 2D and 3D nanocomposite matrices were the subjects of comparison. Medical potential of the SLS/M-fabricated nano-oxide ceramics after additional heating as the basis for tissue engineering scaffolds and cell targeting systems were discussed.

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Igor Shishkovsky, Vladimir Scherbakov, Vladislav Volchkov, and Larisa Volova "Laser-assisted nanoceramics reinforced polymer scaffolds for tissue engineering: additional heating and stem cells behavior ", Proc. SPIE 10493, Dynamics and Fluctuations in Biomedical Photonics XV, 104931T (14 February 2018); https://doi.org/10.1117/12.2290583

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