Monitoring circulating prostate tumor cells after tumor resection by in vivo flow cytometry

Nan Ding; Xi Zhu; Chengying Xie; Dan Wei; Zhangru Yang; Yuanzhen Suo; Xunbin Wei

doi:10.1117/12.2289997

19 February 2018 Monitoring circulating prostate tumor cells after tumor resection by in vivo flow cytometry

Nan Ding, Xi Zhu, Chengying Xie, Dan Wei, Zhangru Yang, Yuanzhen Suo, Xunbin Wei

Proceedings Volume 10495, Biophotonics and Immune Responses XIII; 1049508 (2018) https://doi.org/10.1117/12.2289997
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Prostate cancer has already become the biggest threat among all cancer types for male people and many people died because of its bone metastases. Circulating tumor cells (CTCs) can be used as early metastasis marker so that the detection of CTCs in blood is meaningful for early diagnosis and treatment. However, the relationship between these therapies and metastasis has not been fully clarified yet. Hence, we built PC3 subcutaneous tumor model and developed in vivo flow cytometer (IVFC) platform to record the dynamics of CTC before and after tumor resection. We found out that tumor resection can reduce CTC quantities instantaneously while having a good control of metastasis. CTC re-occurred 7 days after surgery, which might be correlated with early disseminated and deposited tumors. In conclusion, in vivo flow cytometry (IVFC) is capable of detecting CTC dynamics in prostate subcutaneous tumor model and this method could facilitate further research about relationship between other cancer therapies and circulating tumor cells.

Citation Download Citation

Nan Ding, Xi Zhu, Chengying Xie, Dan Wei, Zhangru Yang, Yuanzhen Suo, and Xunbin Wei "Monitoring circulating prostate tumor cells after tumor resection by in vivo flow cytometry", Proc. SPIE 10495, Biophotonics and Immune Responses XIII, 1049508 (19 February 2018); https://doi.org/10.1117/12.2289997

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