RGD peptide-targeted polyethylenimine-entrapped gold nanoparticles for targeted CT imaging of an orthotopic model of human hepatocellular carcinoma

Benqing Zhou; Meng Wang; Feifan Zhou; Jun Song; Junle Qu II; Wei R. Chen

doi:10.1117/12.2285290

19 February 2018 RGD peptide-targeted polyethylenimine-entrapped gold nanoparticles for targeted CT imaging of an orthotopic model of human hepatocellular carcinoma

Benqing Zhou, Meng Wang, Feifan Zhou, Jun Song, Junle Qu II, Wei R. Chen

Author Affiliations +

Proceedings Volume 10495, Biophotonics and Immune Responses XIII; 104950O (2018) https://doi.org/10.1117/12.2285290
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

We report the synthesis and characterization of arginine-glycine-aspartic acid (RGD) peptide-targeted polyethylenimine (PEI)-entrapped gold nanoparticles (RGD-Au PENPs) for targeted CT imaging of hepatic carcinomas in situ. In this work, PEI sequentially modified with polyethylene glycol (PEG), and RGD linked-PEG was used as a nanoplatform to prepare AuNPs, followed by complete acetylation of PEI surface amines. We showed that the designed RGD-Au PENPs were colloidally stable and biocompatible in the given concentration range, and could be specifically taken up by α_vβ₃ integrin-overexpressing liver cancer cells in vitro. Furthermore, in vivo CT imaging results revealed that the particles displayed a great contrast enhancement of hepatic carcinomas region, and could target to hepatic carcinomas region in situ. With the proven biodistribution and histological examinations in vivo, the synthesized RGD-Au PENPs show a great formulation to be used as a contrast agent for targeted CT imaging of different αvβ3 integrin receptoroverexpressing tumors.

Citation Download Citation

Benqing Zhou, Meng Wang, Feifan Zhou, Jun Song, Junle Qu II, and Wei R. Chen "RGD peptide-targeted polyethylenimine-entrapped gold nanoparticles for targeted CT imaging of an orthotopic model of human hepatocellular carcinoma", Proc. SPIE 10495, Biophotonics and Immune Responses XIII, 104950O (19 February 2018); https://doi.org/10.1117/12.2285290

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