The role and mechanics of dendritic cells in tumor antigen acquisition and presentation following laser immunotherapy

Sean M. Laverty; Bryan A. Dawkins; Wei R. Chen

doi:10.1117/12.2291694

19 February 2018 The role and mechanics of dendritic cells in tumor antigen acquisition and presentation following laser immunotherapy

Sean M. Laverty, Bryan A. Dawkins, Wei R. Chen

Author Affiliations +

Proceedings Volume 10495, Biophotonics and Immune Responses XIII; 1049510 (2018) https://doi.org/10.1117/12.2291694
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

We extend our model of the antitumor immune response initiated by laser-immunotherapy treatment to more closely examine key steps in the immune response 1) tumor antigen acquisition by antigen-presenting dendritic cells (DCs) and 2) cytotoxic T cell (CTL) priming by lymphatic DCs. Specifically we explore the formation of DC-CTL complexes that lead to CTL priming. We find that the bias in the dissociation rate of the complex influences the outcome of treatment. In particular, a bias towards priming favors a rapid activated CTL response and the clearance of tumors.

Citation Download Citation

Sean M. Laverty, Bryan A. Dawkins, and Wei R. Chen "The role and mechanics of dendritic cells in tumor antigen acquisition and presentation following laser immunotherapy", Proc. SPIE 10495, Biophotonics and Immune Responses XIII, 1049510 (19 February 2018); https://doi.org/10.1117/12.2291694

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