Ex-vivo mice mammary glands characterization using energy-dispersive x-ray diffraction and spacially resolved CdZnTe detectors

Vera Feldman; Joachim Tabary; Caroline Paulus; Jean-Louis Hazemann; Odile Filhol; Isabelle Vilgrain; Loïck Verger

doi:10.1117/12.2292866

9 March 2018 Ex-vivo mice mammary glands characterization using energy-dispersive x-ray diffraction and spacially resolved CdZnTe detectors

Vera Feldman, Joachim Tabary, Caroline Paulus, Jean-Louis Hazemann, Odile Filhol, Isabelle Vilgrain, Loïck Verger

Author Affiliations +

Proceedings Volume 10573, Medical Imaging 2018: Physics of Medical Imaging; 105732B (2018) https://doi.org/10.1117/12.2292866
Event: SPIE Medical Imaging, 2018, Houston, Texas, United States

Abstract

False-positive mammography results in breast cancer diagnosis can lead to unnecessary biopsies which are invasive and time-consuming. X-Ray Diffraction (XRD) has the potential of providing diagnosis-relevant information and thus can be used after a mammography to verify its results and possibly avoid needless biopsy. We present an energy-dispersive X-Ray Diffraction (EDXRD) system and data analysis method which allowed us to characterize healthy and cancerous mice mammary glands ex-vivo. Our technique showed decent glad localization along the z-axis as well as scatter signatures coherent with ones previously described in literature. We used an in-house spatially resolved CdZnTe detector, and a subpixelation technique which enhances spatial resolution. Acquisition time and dose delivered are to be optimized yet, however our results demonstrate the potential of EDXRD systems for depth-resolved breast imaging. Different geometries and processing algorithms are currently being investigated in the development of a future EDXRD clinical system for breast cancer diagnosis.

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Vera Feldman, Joachim Tabary, Caroline Paulus, Jean-Louis Hazemann, Odile Filhol, Isabelle Vilgrain, and Loïck Verger "Ex-vivo mice mammary glands characterization using energy-dispersive x-ray diffraction and spacially resolved CdZnTe detectors", Proc. SPIE 10573, Medical Imaging 2018: Physics of Medical Imaging, 105732B (9 March 2018); https://doi.org/10.1117/12.2292866

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