Comparative study of human blood Raman spectra and biochemical analysis of patients with cancer

Lyudmila A. Shamina; Ivan A. Bratchenko; Dmitry N. Artemyev; Oleg O. Myakinin; Alexander A. Moryatov; Andrey E. Orlov; Sergey V. Kozlov; Valery P. Zakharov

doi:10.1117/12.2315073

26 April 2018 Comparative study of human blood Raman spectra and biochemical analysis of patients with cancer

Lyudmila A. Shamina, Ivan A. Bratchenko, Dmitry N. Artemyev, Oleg O. Myakinin, Alexander A. Moryatov, Andrey E. Orlov, Sergey V. Kozlov, Valery P. Zakharov

Author Affiliations +

Proceedings Volume 10716, Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX; 107160D (2018) https://doi.org/10.1117/12.2315073
Event: Saratov Fall Meeting 2017, 2017, Saratov, Russian Federation

Abstract

In this study we measured spectral features of blood by Raman spectroscopy. Correlation of the obtained spectral data and biochemical studies results is investigated. Analysis of specific spectra allows for identification of informative spectral bands proportional to components whose content is associated with body fluids homeostasis changes at various pathological conditions. Regression analysis of the obtained spectral data allows for discriminating the lung cancer from other tumors with a posteriori probability of 88.3%. The potentiality of applying surface-enhanced Raman spectroscopy with utilized experimental setup for further studies of the body fluids component composition was estimated. The greatest signal amplification was achieved for the gold substrate with a surface roughness of ~ 1 μm. In general, the developed approach of body fluids analysis provides the basis of a useful and minimally invasive method of pathologies screening.

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Lyudmila A. Shamina, Ivan A. Bratchenko, Dmitry N. Artemyev, Oleg O. Myakinin, Alexander A. Moryatov, Andrey E. Orlov, Sergey V. Kozlov, and Valery P. Zakharov "Comparative study of human blood Raman spectra and biochemical analysis of patients with cancer", Proc. SPIE 10716, Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX, 107160D (26 April 2018); https://doi.org/10.1117/12.2315073

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