The estimation of hemodynamic signals measured by fNIRS response to cold pressor test

M. A. Ansari; E. Fazliazar

doi:10.1117/12.2314704

26 April 2018 The estimation of hemodynamic signals measured by fNIRS response to cold pressor test

M. A. Ansari, E. Fazliazar

Proceedings Volume 10717, Saratov Fall Meeting 2017: Laser Physics and Photonics XVIII; and Computational Biophysics and Analysis of Biomedical Data IV; 1071720 (2018) https://doi.org/10.1117/12.2314704
Event: Saratov Fall Meeting 2017, 2017, Saratov, Russian Federation

Abstract

The estimation of cerebral hemodynamic signals has an important role for monitoring the stage of neurological diseases. Functional Near-Infrared Spectroscopy (fNIRS) can be used for monitoring of brain activities. fNIRS utilizes light in the near-infrared spectrum (650-1000 nm) to study the response of the brain vasculature to the changes in neural activities, called neurovascular coupling, within the cortex when cognitive activation occurs. The neurovascular coupling may be disrupted in the brain pathological condition. Therefore, we can also use fNIRS to diagnosis brain pathological conditions or to monitor the efficacy of related treatments. The Cold pressor test (CPT), followed by immersion of dominant hand or foot in the ice water, can induce cortical activities. The perception of pain induced by CPT can be related to cortical neurovascular coupling. Hence, the variation of cortical hemodynamic signals during CPT can be an indicator for studying neurovascular coupling. Here, we study the effect of pain induced by CPT on the temporal variation of concentration of oxyhemoglobin [HbO₂] and deoxyhemoglobin [Hb] in the healthy brains. We use fNIRS data collected on forehead during a CPT from 11 healthy subjects, and the average data are compared with post-stimulus pain rating scores. The results show that the variation of [Hb] and [HbO₂] are positively correlated with self-reported scores during the CPT. These results depict that fNIRS can be potentially applied to study the decoupling of neurovascular process in brain pathological conditions.

Citation Download Citation

M. A. Ansari and E. Fazliazar "The estimation of hemodynamic signals measured by fNIRS response to cold pressor test", Proc. SPIE 10717, Saratov Fall Meeting 2017: Laser Physics and Photonics XVIII; and Computational Biophysics and Analysis of Biomedical Data IV, 1071720 (26 April 2018); https://doi.org/10.1117/12.2314704

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KEYWORDS

Hemodynamics

Brain

Neurovascular coupling

Sensors

Signal to noise ratio

Dementia

Functional magnetic resonance imaging

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