Optical coherence tomography (OCT) examination of living kidney – animal study

Weijun Li; Yuhong Fang; Junxia Li; Wei Gong; Yongzeng Li; Shushen Xie; Zheng Huang

doi:10.1117/12.2502718

5 November 2018 Optical coherence tomography (OCT) examination of living kidney – animal study

Weijun Li, Yuhong Fang, Junxia Li, Wei Gong, Yongzeng Li, Shushen Xie, Zheng Huang

Proceedings Volume 10816, Advanced Optical Imaging Technologies; 108160J (2018) https://doi.org/10.1117/12.2502718
Event: SPIE/COS Photonics Asia, 2018, Beijing, China

Abstract

Optical coherence tomography (OCT) is an imaging technology which can be used to obtain the high resolution cross sectional image of living biological tissues. It has been used to evaluate the structure and function of animal and human kidneys. Preliminary animal and human data suggest that OCT imaging might be a useful non-invasive tool for characterizing renal tubular lumens, such as the opening status of tubular lumens. In this pilot study, living animal kidneys (dog, rat and mouse) were imaged using a swept source OCT (SS OCT) or spectral domain OCT(SD OCT). In vivo imaging scans were carried out using an OCT microscope setup (5×) and by placing the imaging probe above the surface of the living kidney. Semi-quantitative analysis of the OCT images was performed to evaluate the density of the kidney tubules on the surface layer of the cortex. In addition, histological images of the kidneys were restructured to form nephron three-dimensional structure for comparison with the 3D OCT imaging. This study suggests that quantitative OCT imaging might be useful for visualizing the fine structure of the living kidney and determining the density of renal tubules.

Citation Download Citation

Weijun Li, Yuhong Fang, Junxia Li, Wei Gong, Yongzeng Li, Shushen Xie, and Zheng Huang "Optical coherence tomography (OCT) examination of living kidney – animal study", Proc. SPIE 10816, Advanced Optical Imaging Technologies, 108160J (5 November 2018); https://doi.org/10.1117/12.2502718

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available