Direct comparison of spatial frequency domain imaging, laser speckle imaging and thermal imaging to standard of care clinical assessment in a graded model of burn severity  (Conference Presentation)

Adrien Ponticorvo; Rebecca Rowland; David M. Burmeister; Robert J. Christy; Nicole Bernal; Anthony J. Durkin

doi:10.1117/12.2510609

4 March 2019 Direct comparison of spatial frequency domain imaging, laser speckle imaging and thermal imaging to standard of care clinical assessment in a graded model of burn severity (Conference Presentation)

Adrien Ponticorvo, Rebecca Rowland, David M. Burmeister, Robert J. Christy, Nicole Bernal, Anthony J. Durkin

Author Affiliations +

Proceedings Volume 10851, Photonics in Dermatology and Plastic Surgery 2019; 108510Q (2019) https://doi.org/10.1117/12.2510609
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

While most superficial (first degree) burns and full thickness (third degree) burns are easily diagnosed through standard clinical inspection, burns that fall between these extremes are challenging to accurately classify based on clinical appearance alone. Accurate early assessments have the potential to enable earlier debridement and grafting, thereby reducing complication rates, healing times, and chances for infection. To this end, several emerging technologies aim to objectively and non-invasively quantify burn severity, including Spatial Frequency Domain Imaging (SFDI), Laser Speckle Imaging (LSI), and infrared thermal imaging (IR). While these imaging modalities have some diagnostic ability for in-vivo assessment of burn severity, they have not been directly compared in a controlled experiment. Here we compare the ability of these techniques to assess the severity of graded burns in a porcine model (n=96 burns, 6 pigs). Biopsies were taken for histological analysis to verify burn severity. Clinical assessment, SFDI, LSI and thermal imaging were performed for all graded burns at 24 and 72 hours post-burn. In terms of accuracy of burn severity assessment, using histology as a reference, SFDI (85%) and clinical analysis (83%) performed significantly better that LSI (75%) and thermography (73%) at the 24 hour post-burn time point. There was no statistically significant improvement in assessment accuracy at the 72 hour post-burn time point, across the imaging modalities. These data indicate that SFDI may provide valuable information to clinicians in future clinical trials. This information can be obtained early in the process, which may hasten surgical intervention and reduce complications.

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Adrien Ponticorvo, Rebecca Rowland, David M. Burmeister, Robert J. Christy, Nicole Bernal, and Anthony J. Durkin "Direct comparison of spatial frequency domain imaging, laser speckle imaging and thermal imaging to standard of care clinical assessment in a graded model of burn severity (Conference Presentation)", Proc. SPIE 10851, Photonics in Dermatology and Plastic Surgery 2019, 108510Q (4 March 2019); https://doi.org/10.1117/12.2510609

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KEYWORDS

Thermography

Laser speckle imaging

Speckle imaging

Thermal modeling

Infrared imaging

Diagnostics

Infrared radiation

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