Overcoming chemoresistance using tumor mitochondria-targeted photodynamic therapy

Yang Liu; Jing Cui; Meng Su; Dawei Zhang; Mingfeng Bai

doi:10.1117/12.2508085

28 February 2019 Overcoming chemoresistance using tumor mitochondria-targeted photodynamic therapy

Yang Liu, Jing Cui, Meng Su, Dawei Zhang, Mingfeng Bai

Proceedings Volume 10860, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVIII; 1086006 (2019) https://doi.org/10.1117/12.2508085
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Chemoresistance is a significant challenge in the treatment of patients with ovarian cancer. An important mechanism in resistance to cisplatin is increased drug efflux from tumor cells, potentially mediated by ATPdependent factors such as the ATPases, ATP7A/ATP7B, and the ATP binding cassette (ABC) family member, MRP2. Therefore, a promising strategy to overcome chemoresistance is targeted inhibition of ATP production in tumor cells. In this work, we developed a mitochondria-targeted photodynamic therapy (PDT) approach in ovarian tumors to overcome chemoresistance.

Citation Download Citation

Yang Liu, Jing Cui, Meng Su, Dawei Zhang, and Mingfeng Bai "Overcoming chemoresistance using tumor mitochondria-targeted photodynamic therapy", Proc. SPIE 10860, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVIII, 1086006 (28 February 2019); https://doi.org/10.1117/12.2508085

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