Wide field speckle imaging for the investigation of cerebral blood flow in vivo in murine model of obesity

F. Pain; H. Soleimanzad; F. Smekens; C. Magnan; H. Gurden

doi:10.1117/12.2510077

1 March 2019 Wide field speckle imaging for the investigation of cerebral blood flow in vivo in murine model of obesity

F. Pain, H. Soleimanzad, F. Smekens, C. Magnan, H. Gurden

Proceedings Volume 10865, Neural Imaging and Sensing 2019; 108650V (2019) https://doi.org/10.1117/12.2510077
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

The morphological and functional changes in cerebral blood vessels network is not well characterized in mice models of obesity. In order to study the hemodynamics of these models at rest and during sensory stimulation, we have developed a multi exposure speckle imaging system. It allows wide field superficial imaging of blood flow of the mice cortex. We have characterized the performances of the system using microfluidic phantoms. The capacity of the technique to retrieve accurate relative flow values was studied as a function of the diameter of vessels and the scatterers concentration. New biological data have been obtained in mice models of obesity (high fat diet mice) at rest and under sensory activation.

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Citation Download Citation

F. Pain, H. Soleimanzad, F. Smekens, C. Magnan, and H. Gurden "Wide field speckle imaging for the investigation of cerebral blood flow in vivo in murine model of obesity", Proc. SPIE 10865, Neural Imaging and Sensing 2019, 108650V (1 March 2019); https://doi.org/10.1117/12.2510077

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