Characterization of lymph node optical properties for phantom fabrication

Veronica C. Torres; Todd Wilson; Chengyue Li; Lagnojita Sinha; Jovan G. Brankov; Kenneth M. Tichauer

doi:10.1117/12.2513245

26 February 2019 Characterization of lymph node optical properties for phantom fabrication

Veronica C. Torres, Todd Wilson, Chengyue Li, Lagnojita Sinha, Jovan G. Brankov, Kenneth M. Tichauer

Proceedings Volume 10868, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII; 1086813 (2019) https://doi.org/10.1117/12.2513245
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Sentinel lymph node biopsy is a primary mean of staging cancer; however, the time-intensive nature of standard pathology limits the volume of the node that can be assessed. As a result, micrometastases can be missed, which have been shown to affect treatment decisions and therefore clinical outcomes. Optical imaging offers a potential solution for improved sensitivity and larger tissue evaluation, but an understanding of optical properties is necessary because of the high scattering nature of biological tissue. Here, time-domain optical imaging and measures of transmittance are used to characterize the optical properties of porcine lymph nodes at 685 nm and 780 nm. Results demonstrated values comparable to that of other soft biological tissue (685 nm: μ_a = 0.09 ± 0.01cm^-1 , μ_s’ = 2.60 ± 0.42 cm^-1 , g = 0.95; 780 nm: μ_a = 0.24 ± 0.10cm^-1 , μ_s’ = 3.35 ± 0.14 cm^-1 , g = 0.92). Based on these coefficients, optical properties of TiO₂ were investigated so that a protocol to fabricate a lymph node tissue-mimicking phantom could be defined.

Conference Presentation

Citation Download Citation

Veronica C. Torres, Todd Wilson, Chengyue Li, Lagnojita Sinha, Jovan G. Brankov, and Kenneth M. Tichauer "Characterization of lymph node optical properties for phantom fabrication", Proc. SPIE 10868, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII, 1086813 (26 February 2019); https://doi.org/10.1117/12.2513245

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