Signal-to-noise improvement in LED-based photoacoustic imaging systems using double-stage delay-multiply-and-sum image reconstruction method

Moein Mozaffarzadeh; Ali Hariri; Colman Moore; Jesse V. Jokerst

doi:10.1117/12.2507846

27 February 2019 Signal-to-noise improvement in LED-based photoacoustic imaging systems using double-stage delay-multiply-and-sum image reconstruction method

Moein Mozaffarzadeh, Ali Hariri, Colman Moore, Jesse V. Jokerst

Author Affiliations +

Proceedings Volume 10878, Photons Plus Ultrasound: Imaging and Sensing 2019; 108784E (2019) https://doi.org/10.1117/12.2507846
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Photoacoustic imaging (PAI) is an emerging medical imaging modality which provides the resolution of ultra- sound imaging and contrast of optical imaging. Usually, in conventional PAI systems, high energy Nd:YAG lasers are used for illumination, but they are bulky and expensive. To address these problems, pulse laser diodes and light emitting diodes (LEDs) have been used in PAI imaging systems. LEDs have a lower energy, compared to Nd:YAG lasers. As a result, a lower signal-to-noise (SNR) is achieved. To address this problem, photoacoustic signal averaging is used necessitating a high number of LEDs illuminations. This method is not suitable for applications which the imaging sample is not motionless. In this paper, we propose to use an advanced image reconstruction method, known as double-stage delay multiply and sum (DS-DMAS), to address the low SNR of the data collected from an LED-based scanner. DS-DMAS addresses the low SNR inherent to the LED-based excitation. The results show that this algorithm compensates the low SNR of LED-based systems and provides a lateral resolution of about 60 %, 25 %, higher contrast ratio of about 97 %, 34 %, and better full-width-half- maximum of about 60 %, 25 %, in comparison with the delay-and-sum and delay-multiply-and-sum, respectively. Additionally, only 2 % of all the frames are used in DS-DMAS, which indicates that DS-DMAS uses a smaller number of frames to provide a high image quality.

Citation Download Citation

Moein Mozaffarzadeh, Ali Hariri, Colman Moore, and Jesse V. Jokerst "Signal-to-noise improvement in LED-based photoacoustic imaging systems using double-stage delay-multiply-and-sum image reconstruction method", Proc. SPIE 10878, Photons Plus Ultrasound: Imaging and Sensing 2019, 108784E (27 February 2019); https://doi.org/10.1117/12.2507846

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KEYWORDS

Signal detection

Signal to noise ratio

Light emitting diodes

Imaging systems

Photoacoustic spectroscopy

Photoacoustic imaging

Chromium

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