Subcellular localization of gold nanorods in cancerous cells

Sana Mesiya; Austin Doughty; Benqing Zhou; Elivia Layton; Feifan Zhou; Wei R. Chen

doi:10.1117/12.2510979

7 March 2019 Subcellular localization of gold nanorods in cancerous cells

Sana Mesiya, Austin Doughty, Benqing Zhou, Elivia Layton, Feifan Zhou, Wei R. Chen

Proceedings Volume 10879, Biophotonics and Immune Responses XIV; 1087917 (2019) https://doi.org/10.1117/12.2510979
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Gold nanorods (GNRs) have the potential for cancer treatment as tumor-targeting photosensitizers due to their strong absorption of near-infrared light. The purpose of this project was to study the subcellular localization of GNRs in cancerous to optimize cancer treatment using irradiation at appropriate wavelength. Subcellular localization of gold nanorods has been shown to have a significant impact on the retention or exclusion of GNRs within the cells as well as cell viability and morphology. GNRs were functionalized with a fluorescent dye, incubated with cells, and then imaged using a fluorescent microscope. Our results demonstrated the localization of GNRs in cancer cell mitochondria and lysosomes, which corroborates the findings of other studies. Further studies will determine the functions of the subcellular GNRs under irradiation of laser of appropriate wavelengths. Our research could lead to a targeted, effective nanotechnology based laser immunotherapy.

Citation Download Citation

Sana Mesiya, Austin Doughty, Benqing Zhou, Elivia Layton, Feifan Zhou, and Wei R. Chen "Subcellular localization of gold nanorods in cancerous cells", Proc. SPIE 10879, Biophotonics and Immune Responses XIV, 1087917 (7 March 2019); https://doi.org/10.1117/12.2510979

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