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4 March 2019 Acoustic z-focus control for high-speed volumetric optical microscopy (Conference Presentation)
Marti Duocastella
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Proceedings Volume 10889, High-Speed Biomedical Imaging and Spectroscopy IV; 108890E (2019) https://doi.org/10.1117/12.2507749
Event: SPIE BiOS, 2019, San Francisco, California, United States
Abstract
The real-time characterization of fast-evolving processes with sub-cellular resolution is crucial to unveil biological mechanisms as relevant as brain function or intracellular diffusion. Optical microscopes are optimal tools for 2D imaging of living organisms, but the need for z-focus translation significantly constraints volumetric imaging speed. In this talk, I will show how an acoustic optofluidic lens enables z-focus scanning at rates as high as 1 MHz. Such unsurpassed speed opens the door to novel strategies in 3D confocal and light-sheet systems in which the temporal and spatial resolution can be user-selected based on application, well-beyond the limits of traditional microscopes.
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Marti Duocastella "Acoustic z-focus control for high-speed volumetric optical microscopy (Conference Presentation)", Proc. SPIE 10889, High-Speed Biomedical Imaging and Spectroscopy IV, 108890E (4 March 2019); https://doi.org/10.1117/12.2507749
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KEYWORDS
Acoustics
Optical microscopy
Brain
Confocal microscopy
Diffusion
Microscopes
Optical microscopes
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