Research and development of effective optical technologies for diagnostics in dermatology

Vadim D. Genin; Prisca Rakotomanga; Sergey M. Zaytsev; Elina A. Genina; Ekaterina N. Lazareva; Grégoire Khairallah; Marine Amouroux; Charles Soussen; Hang Chen; Wei Feng; Dan Zhu; Alexey N. Bashkatov; Walter Blondel; Valery V. Tuchin

doi:10.1117/12.2528700

3 June 2019 Research and development of effective optical technologies for diagnostics in dermatology

Vadim D. Genin, Prisca Rakotomanga, Sergey M. Zaytsev, Elina A. Genina, Ekaterina N. Lazareva, Grégoire Khairallah, Marine Amouroux, Charles Soussen, Hang Chen, Wei Feng, Dan Zhu, Alexey N. Bashkatov, Walter Blondel, Valery V. Tuchin

Author Affiliations +

Proceedings Volume 11065, Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine; 1106505 (2019) https://doi.org/10.1117/12.2528700
Event: International Symposium on Optics and Biophotonics VI: Saratov Fall Meeting 2018, 2018, Saratov, Russian Federation

Abstract

Optical clearing of the human skin under the action of hyaluronic acid (HA) as an enhancer for optical clearing by polyethylene glycol (PEG-300) was studied in vivo by optical coherent tomography (OCT) method on the wavelength 930±5 nm. The results have showed an increase in the transparency of the epidermis at the optical depth of 50±5 μm by 44±9% within 15 min with the use of a solution of HA in combination with sonophoresis before application of PEG-300 to the skin surface. At the same time, when using PEG-300 without preliminary treatment of the skin with the HA, an increase in the transparency of the epidermis at the same depth was 21±8% within 25 min. In dermis at the depth of 500 μm the OCT signal in the experimental group increased more than 1.6 fold what indicates an increasing of optical probing depth.

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Vadim D. Genin, Prisca Rakotomanga, Sergey M. Zaytsev, Elina A. Genina, Ekaterina N. Lazareva, Grégoire Khairallah, Marine Amouroux, Charles Soussen, Hang Chen, Wei Feng, Dan Zhu, Alexey N. Bashkatov, Walter Blondel, and Valery V. Tuchin "Research and development of effective optical technologies for diagnostics in dermatology", Proc. SPIE 11065, Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine, 1106505 (3 June 2019); https://doi.org/10.1117/12.2528700

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