Photodynamic therapy as an alternative to antibiotic therapy for the treatment of infected leg ulcers (Conference Presentation)

Aleksandra Kawczyk-Krupka; Anna Król-Zybura; Aleksander Sieroń; Grzegorz Cieslar

doi:10.1117/12.2525525

14 August 2019 Photodynamic therapy as an alternative to antibiotic therapy for the treatment of infected leg ulcers (Conference Presentation)

Aleksandra Kawczyk-Krupka, Anna Król-Zybura, Aleksander Sieroń, Grzegorz Cieslar

Author Affiliations +

Proceedings Volume 11070, 17th International Photodynamic Association World Congress; 1107022 (2019) https://doi.org/10.1117/12.2525525
Event: 17th International Photodynamic Association World Congress, 2019, Cambridge, Massachusetts, United States

Abstract

Background and Objective Chronic and infected leg ulcers (LUs) are painful, debilitating, resistant to antibiotics, immensely reducing patient's quality of life. The purpose of the new clinical research project was to demonstrate the the efficacy of photodynamic therapy (PDT) as an alternative to antibiotic therapy for the treatment of infected chronic LUs. Patients and Methods PDT using irradiation at fluency 80 J / cm2 and 20% 5-aminolevulinic acid topically applied for 4 hrs, was performed during 10 days of hospitalization in 10 patients both sexes aged 40-85, with chronic leg ulcers, who had not responded well to conventional treatment. This was a randomized, placebo-controlled trial (local Octenidine dihydrochloride). The numerical scale of pain was used. Treatments were carried out at 3-week intervals. Result During 8 months follow up, complete remission (CR) was obtained in 4 patients (40%), partial response (>50% reduction in ulcer diameter), in 3 patients (30%), no response in 1 patients (10%). In two patients (20%) was observed deterioration of the local condition, with swelling, erythema and inflammation. Conclusion PDT allowed healing of chronic leg ulcers through the antimicrobial effect, modulation of inflammatory process and improving the oxygenation of ulcer tissue with a reduction in healing time and improving scarring results with the reduction of pathological bacterial culture. Further studies on the larger group of patients are needed to confirm the benefit role of PDT in the treatment of LUs.

Conference Presentation

Citation Download Citation

Aleksandra Kawczyk-Krupka, Anna Król-Zybura, Aleksander Sieroń, and Grzegorz Cieslar "Photodynamic therapy as an alternative to antibiotic therapy for the treatment of infected leg ulcers (Conference Presentation)", Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 1107022 (14 August 2019); https://doi.org/10.1117/12.2525525

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Photodynamic therapy

Lutetium

Chromium

Clinical research

Inflammation

Modulation

Tissues

Keywords/Phrases

Search In:

Publication Years