5-ALA induces the distribution of endogenous PpIX fluorescence in cervical lesions

XiaoLi Lu; GuangZhi Liu; LiYun Yang; GuiQin Chen; LeNan Cheng; Bing Mao; ZiYi Zhao; QiuYun Yang

doi:10.1117/12.2525359

7 August 2019 5-ALA induces the distribution of endogenous PpIX fluorescence in cervical lesions

XiaoLi Lu, GuangZhi Liu, LiYun Yang, GuiQin Chen, LeNan Cheng, Bing Mao, ZiYi Zhao, QiuYun Yang

Proceedings Volume 11070, 17th International Photodynamic Association World Congress; 1107073 (2019) https://doi.org/10.1117/12.2525359
Event: 17th International Photodynamic Association World Congress, 2019, Cambridge, Massachusetts, United States

Abstract

Objective: To investigate the distribution of ALA in Cervical lesion tissue by tissue frozen section and fluorescence microscopy. Methods: 20% of 5-ALA were topically applied to the cervix.Biopsies were taken from the lesions for histology examination, Fluorescence microscopy was performed methods in these frozen section of cervical tissue to observe the distribution of ALA and the result was analyzed semi-quantitatively. Results: The maximal Protoporphyrin IX (PpIX) fluorescence was observed in the most serious tissue with cervical lesions .fluorescence photometry corroborated these results. Conclusion: ALA is selectively accumulated in cervical lesions, and the more severe the lesion, the easier it is to accumulate.

Citation Download Citation

XiaoLi Lu, GuangZhi Liu, LiYun Yang, GuiQin Chen, LeNan Cheng, Bing Mao, ZiYi Zhao, and QiuYun Yang "5-ALA induces the distribution of endogenous PpIX fluorescence in cervical lesions", Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 1107073 (7 August 2019); https://doi.org/10.1117/12.2525359

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KEYWORDS

Luminescence

Tissues

Microscopy

Photodynamic therapy

Tissue optics

Biopsy

Clinical medicine

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