Raman spectroscopic investigation of plasma by drop coating deposition for clinical application

Jing Huang; Anuradha Ramoji; Michael Kiehntopf; Michel Noutsias; Shuxia Guo; Thomas Bocklitz; Jürgen Popp; Ute Neugebauer

doi:10.1117/12.2526738

19 July 2019 Raman spectroscopic investigation of plasma by drop coating deposition for clinical application

Jing Huang, Anuradha Ramoji, Michael Kiehntopf, Michel Noutsias, Shuxia Guo, Thomas Bocklitz, Jürgen Popp, Ute Neugebauer

Author Affiliations +

Proceedings Volume 11073, Clinical and Preclinical Optical Diagnostics II; 1107306 (2019) https://doi.org/10.1117/12.2526738
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

Raman spectroscopy has been applied to investigate the suitability of the drop coating deposition technique to study plasma samples from healthy donors and a patient with underlying cardiac condition. When blood plasma is deposited on a solid substrate, a droplet with coffee-ring is formed, and the plasma proteins will distribute inhomogeneously depending on the chemical and physical properties of the proteins. Changes in the fingerprint region of the Raman spectra were observed from the outer-ring and central zone of the droplet through a systematic investigation. For complete characterization of the sample, optimum measurement scheme has been proposed. To obtain clinically relevant information of the effects of immunoadsorption (IA) treatment of dilated cardiomyopathy (DCM) patient’s, Raman spectral information from outer-ring as well as from the central zone is required.

Citation Download Citation

Jing Huang, Anuradha Ramoji, Michael Kiehntopf, Michel Noutsias, Shuxia Guo, Thomas Bocklitz, Jürgen Popp, and Ute Neugebauer "Raman spectroscopic investigation of plasma by drop coating deposition for clinical application", Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II, 1107306 (19 July 2019); https://doi.org/10.1117/12.2526738

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available