Spectral approach to time domain diffuse optical tomography for breast cancer: validation on meat phantoms

Edoardo Ferocino; Giuseppe Di Sciacca; Laura Di Sieno; Alberto Dalla Mora; Antonio Pifferi; Simon Arridge; Fabrizio Martelli; Paola Taroni; Andrea Farina

doi:10.1117/12.2526649

11 July 2019 Spectral approach to time domain diffuse optical tomography for breast cancer: validation on meat phantoms

Edoardo Ferocino, Giuseppe Di Sciacca, Laura Di Sieno, Alberto Dalla Mora, Antonio Pifferi, Simon Arridge, Fabrizio Martelli, Paola Taroni, Andrea Farina

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Proceedings Volume 11074, Diffuse Optical Spectroscopy and Imaging VII; 1107408 (2019) https://doi.org/10.1117/12.2526649
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

Time Domain Diffuse Optical Tomography (TD-DOT) performed at multiple wavelengths can be used to non-invasively probe tissue composition. Then, tissue composition can be related to breast tissue and lesion type. Thus, TD-DOT could be used for therapy monitoring for breast cancer. We developed a software tool for multi-wavelength TD-DOT and performed a validation on meat phantoms to mimic tissue heterogeneity. An inclusion of different meat was exploited to mimic the presence of a lesion in the breast. Results show good localization of the inclusion, but poor quantification of the reconstructed breast composition. The use of a morphological prior constraint, providing information on inclusion geometry and position, significantly improves both localization and composition estimate.

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Edoardo Ferocino, Giuseppe Di Sciacca, Laura Di Sieno, Alberto Dalla Mora, Antonio Pifferi, Simon Arridge, Fabrizio Martelli, Paola Taroni, and Andrea Farina "Spectral approach to time domain diffuse optical tomography for breast cancer: validation on meat phantoms", Proc. SPIE 11074, Diffuse Optical Spectroscopy and Imaging VII, 1107408 (11 July 2019); https://doi.org/10.1117/12.2526649

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KEYWORDS

Breast cancer

Diffuse optical tomography

Absorption

Scattering

Tissues

Breast

Mie scattering

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