Non-invasive optical assessment of intracranial pressure: pilot results in human patients

Wesley B. Baker; Tracy M. Flanders; Ramani Balu; Lian He; Kristina Heye; Elizabeth Mahanna Gabrielli; John J. Flibotte; Daniel J. Licht; Gregory G. Heuer; Arjun G. Yodh; W. Andrew Kofke

doi:10.1117/12.2527122

11 July 2019 Non-invasive optical assessment of intracranial pressure: pilot results in human patients

Wesley B. Baker, Tracy M. Flanders, Ramani Balu, Lian He, Kristina Heye, Elizabeth Mahanna Gabrielli, John J. Flibotte, Daniel J. Licht, Gregory G. Heuer, Arjun G. Yodh, W. Andrew Kofke

Author Affiliations +

Proceedings Volume 11074, Diffuse Optical Spectroscopy and Imaging VII; 110740F (2019) https://doi.org/10.1117/12.2527122
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

We present pilot results on the validation of non-invasive assessment of elevated intracranial pressure with optical measurement of critical closing pressure. A strong correlation (r=0.85) between optical measurements of critical closing pressure and invasive measurements of intracranial pressure was observed in 5 infants with hydrocephalus, and 1 adult patient with diffuse hypoxic ischemic brain injury. By facilitating timely detection of intracranial hypertension, this approach has potential to reduce risk of brain damage in hydrocephalus and other vulnerable patient populations.

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Wesley B. Baker, Tracy M. Flanders, Ramani Balu, Lian He, Kristina Heye, Elizabeth Mahanna Gabrielli, John J. Flibotte, Daniel J. Licht, Gregory G. Heuer, Arjun G. Yodh, and W. Andrew Kofke "Non-invasive optical assessment of intracranial pressure: pilot results in human patients", Proc. SPIE 11074, Diffuse Optical Spectroscopy and Imaging VII, 110740F (11 July 2019); https://doi.org/10.1117/12.2527122

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