Functionalized upconversion luminescent nanoparticles for theranostics

Irina Yu Yanina; Nikita A. Navolokin; Irina V. Vidyasheva; Irina Yu. Goryacheva; Vyacheslav I. Kochubey; Valery V. Tuchin

doi:10.1117/12.2526930

11 July 2019 Functionalized upconversion luminescent nanoparticles for theranostics

Irina Yu Yanina, Nikita A. Navolokin, Irina V. Vidyasheva, Irina Yu. Goryacheva, Vyacheslav I. Kochubey, Valery V. Tuchin

Author Affiliations +

Proceedings Volume 11074, Diffuse Optical Spectroscopy and Imaging VII; 1107419 (2019) https://doi.org/10.1117/12.2526930
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

The luminescence spectra of upconversion nanoparticles (UCNPs) and functionalized UCNPs (UCNPs+folic acid) delivered via subcutaneous and intratumor injection into rats were measured. The particles in normal skin do not diffuse and dissolve, but remain at the introduction site. Inflammatory reaction is developing in the skin when UCNPs were injected. The dense connective tissue capsule is formed around the particles in 3 days after administration. UCNPs were located in the tumor diffusely after 4 daysof injection. Up to 80-90% of the tumor was necrotized after laser irradiation on the fourth day after UCNP administration.

Citation Download Citation

Irina Yu Yanina, Nikita A. Navolokin, Irina V. Vidyasheva, Irina Yu. Goryacheva, Vyacheslav I. Kochubey, and Valery V. Tuchin "Functionalized upconversion luminescent nanoparticles for theranostics", Proc. SPIE 11074, Diffuse Optical Spectroscopy and Imaging VII, 1107419 (11 July 2019); https://doi.org/10.1117/12.2526930

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available