Optical interferometric temperature sensors for intravascular blood flow measurements

Elizabeth Carr; Eleanor C. Mackle; Malcolm C. Finlay; Charles A. Mosse; Joanna M. Coote; Ioannis Papakonstantinou; Adrien E. Desjardins

doi:10.1117/12.2527056

22 July 2019 Optical interferometric temperature sensors for intravascular blood flow measurements

Elizabeth Carr, Eleanor C. Mackle, Malcolm C. Finlay, Charles A. Mosse, Joanna M. Coote, Ioannis Papakonstantinou, Adrien E. Desjardins

Author Affiliations +

Proceedings Volume 11075, Novel Biophotonics Techniques and Applications V; 1107502 (2019) https://doi.org/10.1117/12.2527056
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

Direct and continuous measurements of blood flow are of significant interest in many medical specialties. In cardiology, intravascular physiological measurements can be of critical importance to determine whether coronary stenting should be performed. Intravascular pressure is a physiological parameter that is frequently measured in clinical practice. An increasing body of evidence suggests that direct measurements of blood flow, as additional physiological parameters, could improve decision making. In this study, we developed a novel fibre optic intravascular flow sensor, which enabled time-of-flight measurements by upstream thermal tagging of blood. This flow sensor comprised a temperature sensitive polymer dome at the distal end of a single mode optical fibre. The dome was continuously interrogated by low coherence interferometry to measure thermally-induced length changes with nanometre-scale resolution. Flow measurements were performed by delivering heat upstream from the sensor with a separate optical fibre, and monitoring the temperature downstream at the dome with a sample rate of 50 Hz. A fabricated flow sensor was characterized and tested within a benchtop phantom, which comprised vessels with lumen diameters that ranged from 2.5 to 5 mm. Water was used as a blood mimicking fluid. For each vessel diameter, a pump provided constant volumetric flow at rates in the range of 5 to 200 ml/min. This range was chosen to represent flow rates encountered in healthy human vessels. Laser light pulses with a wavelength of 1470 nm and durations of 0.4 s were used to perform upstream thermal tagging. These pulses resulted in downstream temperature profiles that varied with the volumetric flow rate.

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Elizabeth Carr, Eleanor C. Mackle, Malcolm C. Finlay, Charles A. Mosse, Joanna M. Coote, Ioannis Papakonstantinou, and Adrien E. Desjardins "Optical interferometric temperature sensors for intravascular blood flow measurements", Proc. SPIE 11075, Novel Biophotonics Techniques and Applications V, 1107502 (22 July 2019); https://doi.org/10.1117/12.2527056

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KEYWORDS

Domes

Temperature sensors

Sensors

Interferometry

Diffusers

Blood

Fiber optics

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