Optical coherence tomography controlled selective retina therapy with a novel microsecond laser

Christian Burri; Alessa Hutfilz; Lorenz Grimm; Patrik Arnold; Andreas Ebneter; Ralf Brinkmann; Dirk Theisen-Kunde; Boris Považay; Christoph Meier

doi:10.1117/12.2526720

22 July 2019 Optical coherence tomography controlled selective retina therapy with a novel microsecond laser

Christian Burri, Alessa Hutfilz, Lorenz Grimm, Patrik Arnold, Andreas Ebneter, Ralf Brinkmann, Dirk Theisen-Kunde, Boris Považay, Christoph Meier

Author Affiliations +

Proceedings Volume 11079, Medical Laser Applications and Laser-Tissue Interactions IX; 1107903 (2019) https://doi.org/10.1117/12.2526720
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

Selective retina therapy (SRT) is a short pulse (μs-regime) alternative to conventional laser photocoagulation (LPC) for treatment of retinal diseases. LPC leads to collateral damage of retinal layers adjacent to the retinal pigment epithelium (RPE), including healthy, non-regenerative photoreceptors due to the high thermal load, whereas in SRT, RPE cells are destroyed by microbubbles without damaging the neuronal retina. A novel experimental SRT laser operating at 532 nm wavelength can deliver 2 – 20 μs pulse sequences. Its tight integration into an upgraded diagnostic SPECTRALIS system combines beam control for treatment planning with real-time optical coherence tomography (OCT) overexposure protection of the photoreceptors. This “Spectralis Centaurus” system, was built and preliminary tested on porcine ex-vivo samples, reaching an unprecedented accuracy with unique planning and follow-up capabilities for upcoming clinical cellular level micro-surgery. The combination of OCT with SRT selectively limits cell death to the RPE by precisely controlling energy deposition while optically monitoring tissue response.

Citation Download Citation

Christian Burri, Alessa Hutfilz, Lorenz Grimm, Patrik Arnold, Andreas Ebneter, Ralf Brinkmann, Dirk Theisen-Kunde, Boris Považay, and Christoph Meier "Optical coherence tomography controlled selective retina therapy with a novel microsecond laser", Proc. SPIE 11079, Medical Laser Applications and Laser-Tissue Interactions IX, 1107903 (22 July 2019); https://doi.org/10.1117/12.2526720

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available