Red and blue light photodynamic therapy regimes: optical monitoring and histology studies

Mikhail Kirillin; Maria Shakhova; Daria Kurakina; Aleksandr Khilov; Anna Orlova; Ekaterina Sergeeva; Alina Meller; Natalia Orlinskaya; Ilya Turchin

doi:10.1117/12.2527061

22 July 2019 Red and blue light photodynamic therapy regimes: optical monitoring and histology studies

Mikhail Kirillin, Maria Shakhova, Daria Kurakina, Aleksandr Khilov, Anna Orlova, Ekaterina Sergeeva, Alina Meller, Natalia Orlinskaya, Ilya Turchin

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Proceedings Volume 11079, Medical Laser Applications and Laser-Tissue Interactions IX; 110790R (2019) https://doi.org/10.1117/12.2527061
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

In this study we present a complex approach to photodynamic therapy (PDT) with chlorin based photosensitizers including Monte Carlo based planning and prediction of optical diagnostics results, intra-procedure dual-wavelength fluorescence monitoring allowing to evaluate PS accumulation and photobleaching, and monitoring of tissue response with optical coherence tomography (OCT). The approach was employed to compare the effects of different PDT regimens in normal and tumor tissues and the results of non-invasive optical diagnostics were matched with results of histologic examination, including hematoxylin-eosin and Mallory staining. The considered doses are in the range 50-150 J/cm² for normal tissues and 150-275 J/cm² for tumor tissues, single wavelength (405 and 660 nm) and dual-wavelength regimes are studied.

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Mikhail Kirillin, Maria Shakhova, Daria Kurakina, Aleksandr Khilov, Anna Orlova, Ekaterina Sergeeva, Alina Meller, Natalia Orlinskaya, and Ilya Turchin "Red and blue light photodynamic therapy regimes: optical monitoring and histology studies", Proc. SPIE 11079, Medical Laser Applications and Laser-Tissue Interactions IX, 110790R (22 July 2019); https://doi.org/10.1117/12.2527061

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KEYWORDS

Photodynamic therapy

Tumors

Picosecond phenomena

Luminescence

Optical coherence tomography

Tissues

Tissue optics

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